Regulation of protein localization to centrosome

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to centrosome pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, NSUN2, and DENND2D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to centrosome activity versus ADNP in HNSC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADNP →	+0.359	+0.091	<.001	<.001	3	7
LSCC	NSUN2 →	+0.288	+0.047	<.001	<.001	3	7
COAD	DENND2D →	-0.288	-0.032	<.001	.001	3	7
HNSC	ECHDC1 →	-0.408	-0.085	<.001	.001	3	6
GBM	EPS8L2_S240 →	-1.047	-0.054	.001	.001	3	6
HNSC	MSH2 →	+0.341	+0.069	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904779 vs ADNP — HNSC

Explore this scatter interactively →