Regulation of protein localization to centrosome

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to centrosome pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR2, LINC02481, and LINC02195, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to centrosome activity versus C5AR2 in GBM (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C5AR2 →	-1.012	-0.782	<.001	<.001	3	4
PDAC	LINC02481 →	-0.455	-0.199	.001	.005	3	4
LUAD	LINC02195 →	-0.667	-0.214	.002	.001	3	4
GBM	NCF1C →	-0.714	-0.562	<.001	<.001	3	4
BRCA	RPL21P123 →	-0.716	-0.346	.001	.002	3	4
BRCA	RPL7AP31 →	-0.914	-0.369	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904779 vs C5AR2 — GBM

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