Regulation of protein localization to centrosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to centrosome pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APC, RAB11A, and TOR1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APC grouped by Regulation of protein localization to centrosome-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	APC →	-0.728	-2.168	.003	<.001	3	8
CNS	RAB11A →	-0.263	-1.146	<.001	<.001	2	7
LUNG_NSCLC_LUSC	TOR1A →	-0.265	-1.496	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF492 →	-0.097	-1.134	.008	.001	3	4
PANCREAS	IL21 →	-0.248	-1.255	.006	.001	3	4
URINARY_TRACT	STK38 →	-0.190	-1.835	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APC by Regulation of protein localization to centrosome activity — STOMACH

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