Regulation of protein localization to centrosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to centrosome pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL, UBC, and LBR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELL grouped by Regulation of protein localization to centrosome-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ELL →	-0.884	-1.614	.002	.003	3	5
BLOOD_Lymphoma	UBC →	-0.935	-2.184	<.001	<.001	3	5
LUNG_NSCLC_LUSC	LBR →	+0.765	+1.422	<.001	<.001	3	4
LARGE_INTESTINE	ACD →	-0.631	-1.286	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	DBI →	+1.502	+1.347	.001	<.001	3	4
LARGE_INTESTINE	AUTS2 →	+1.922	+1.118	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELL by Regulation of protein localization to centrosome activity — SOFT_TISSUE

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