Regulation of protein localization to centrosome

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to centrosome pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPB, PCNA, and TRMT6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to centrosome activity versus SNRPB in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SNRPB →	+0.844	+0.676	<.001	.001	3	4
LUNG_NSCLC_LUAD	PCNA →	+0.924	+0.729	.001	.004	3	4
PANCREAS	TRMT6 →	+1.130	+1.042	.003	.006	3	4
PANCREAS	MCM8 →	+1.202	+1.090	.001	.004	3	4
LUNG_SCLC	ANKEF1 →	+1.013	+0.234	.005	.008	3	3
LUNG_SCLC	IQCB1 →	+0.863	+0.332	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904779 vs SNRPB — LUNG_NSCLC_LUAD

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