Negative regulation of myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myofibroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2_S540, CDC20_T70, and TNS1_S1393, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myofibroblast differentiation activity versus KANK2_S540 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2_S540 →	+0.407	+0.075	<.001	<.001	3	6
UCEC	CDC20_T70 →	-0.902	-0.122	<.001	<.001	3	6
UCEC	TNS1_S1393 →	+0.817	+0.095	.005	.002	3	5
UCEC	TNS2 →	+0.322	+0.091	<.001	<.001	3	5
BRCA	YTHDF2 →	-0.192	-0.093	.007	<.001	3	5
UCEC	GUCY1B1 →	+0.512	+0.102	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904761 vs KANK2_S540 — BRCA

Explore this scatter interactively →