Negative regulation of myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of myofibroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, CGN, and PXDC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Negative regulation of myofibroblast differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDKN1A →	-2.663	-1.426	.005	.003	3	5
BLOOD_Myeloma	CGN →	-2.140	-1.942	.007	<.001	3	5
SOFT_TISSUE	PXDC1 →	+2.962	+1.847	<.001	<.001	3	5
KIDNEY	ZNF844 →	+1.087	+1.303	.001	.003	3	5
LIVER	ANLN →	+1.349	+1.715	.007	.004	1	6
LUNG_SCLC	APBB2 →	+2.026	+1.411	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Negative regulation of myofibroblast differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →