Regulation of myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myofibroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RB1_T356, RPL7L1, and UTP15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myofibroblast differentiation activity versus RB1_T356 in LSCC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RB1_T356 →	+1.421	+0.252	<.001	<.001	3	7
LUAD	RPL7L1 →	+0.292	+0.297	<.001	<.001	3	6
COAD	UTP15 →	+0.281	+0.610	<.001	<.001	3	6
HNSC	UTP4 →	+0.253	+0.185	<.001	<.001	3	6
LSCC	HEATR1 →	+0.269	+0.235	<.001	<.001	3	6
LUAD	NIP7 →	+0.420	+0.366	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904760 vs RB1_T356 — LSCC

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