Positive regulation of vascular associated smooth muscle cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, C1R, and C1S, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell migration activity versus BGN in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BGN →	+0.835	+0.099	.001	<.001	3	9
LSCC	C1R →	+0.503	+0.088	<.001	<.001	3	9
BRCA	C1S →	+0.619	+0.054	<.001	<.001	3	9
GBM	COL3A1 →	+0.841	+0.081	<.001	<.001	3	9
BRCA	SERPING1 →	+0.505	+0.051	<.001	<.001	3	8
OV	SRRM2_S1124 →	-0.481	-0.049	.004	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904754 vs BGN — UCEC

Explore this scatter interactively →