Positive regulation of vascular associated smooth muscle cell migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFEMP2, ACTA2, and SULF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell migration activity versus EFEMP2 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFEMP2 →	+0.767	+0.889	.007	.002	3	5
COAD	ACTA2 →	+0.674	+0.214	.001	.001	3	5
HNSC	SULF1 →	+1.058	+0.758	.001	.005	2	6
BRCA	C5orf46 →	+1.385	+0.611	<.001	<.001	3	5
HNSC	DNM1P51 →	+0.360	+0.724	.007	.003	3	4
BRCA	SUGCT →	+0.887	+0.597	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904754 vs EFEMP2 — OV

Explore this scatter interactively →