Positive regulation of vascular associated smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRNAU1AP, RTCB, and ATP6V1E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell migration activity versus TRNAU1AP in LUNG_NSCLC_LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRNAU1AP →	+0.816	+0.519	<.001	.007	3	4
SKIN	RTCB →	+0.769	+1.043	<.001	.006	3	4
LUNG_SCLC	ATP6V1E1 →	+0.546	+1.078	.006	.007	3	4
LUNG_SCLC	STX19 →	+1.380	+1.079	.001	.001	3	4
LARGE_INTESTINE	AGRN →	-1.672	-0.439	.002	<.001	3	4
LUNG_NSCLC_LUAD	HIVEP2 →	+0.956	+0.514	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904754 vs TRNAU1AP — LUNG_NSCLC_LUAD

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