Negative regulation of vascular associated smooth muscle cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA8, KCNMB1, and LINC01480, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell migration activity versus ABCA8 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ABCA8 →	+0.871	+0.751	.005	<.001	3	6
UCEC	KCNMB1 →	+0.773	+0.426	<.001	<.001	3	5
LSCC	LINC01480 →	+0.584	+0.347	<.001	.002	3	5
HNSC	PLN →	+1.038	+1.056	<.001	<.001	3	5
HNSC	MAGI2-AS3 →	+0.723	+0.798	.002	<.001	3	4
BRCA	EDA2R →	+0.642	+0.483	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904753 vs ABCA8 — OV

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