Negative regulation of vascular associated smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTG2, UBE2H, and CUL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTG2 grouped by Negative regulation of vascular associated smooth muscle cell migration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BTG2 →	-1.094	-0.866	.005	<.001	3	6
BLOOD_Myeloma	UBE2H →	+1.291	+1.868	<.001	<.001	3	5
BREAST	CUL1 →	+0.820	+0.908	.007	.002	3	5
PANCREAS	TMEM105 →	-1.330	-1.567	.003	<.001	3	5
SOFT_TISSUE	KREMEN2 →	-3.190	-1.494	.002	<.001	3	5
BLOOD_Leukemia	SCML2 →	+1.477	+1.104	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTG2 by Negative regulation of vascular associated smooth muscle cell migration activity — CNS

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