Negative regulation of vascular associated smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WIPF2, SLC2A14, and CD7, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WIPF2 grouped by Negative regulation of vascular associated smooth muscle cell migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WIPF2 →	+0.380	+0.296	.003	.007	3	1
SKIN	SLC2A14 →	+0.236	+0.231	.002	.003	3	1
SKIN	CD7 →	+0.225	+0.231	<.001	.003	3	1
SKIN	LRRC3B →	-0.156	-0.231	<.001	.003	3	1
SKIN	SEPTIN3 →	-0.523	-0.278	.001	.008	3	1
SKIN	DDX49 →	+0.277	+0.231	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WIPF2 by Negative regulation of vascular associated smooth muscle cell migration activity — SKIN

Explore this box plot interactively →