Negative regulation of vascular associated smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADSL, RAB1A, and ILK, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell migration activity versus ADSL in SKIN (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADSL →	-0.647	-0.265	.001	.002	3	2
BLOOD_Myeloma	RAB1A →	+0.969	+0.319	.002	.004	2	2
BLOOD_Myeloma	ILK →	+1.299	+0.292	.006	.004	2	2
BLOOD_Leukemia	NXT2 →	-1.116	-0.235	.001	.004	3	1
BLOOD_Leukemia	C3orf22 →	-0.058	-0.853	.005	<.001	3	1
SKIN	DDHD1 →	+0.613	+0.392	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904753 vs ADSL — SKIN

Explore this scatter interactively →