Positive regulation of protein localization to nucleolus

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to nucleolus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBG1, NXF1, and RBM10_S736, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to nucleolus activity versus TUBG1 in OV (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TUBG1 →	-0.365	-0.056	<.001	<.001	3	5
GBM	NXF1 →	-0.193	-0.040	.001	<.001	3	5
BRCA	RBM10_S736 →	-0.526	-0.047	.002	.005	3	5
GBM	ATAD2 →	-0.346	-0.043	<.001	<.001	3	4
GBM	ATAD2_S327 →	-0.778	-0.088	<.001	<.001	3	4
GBM	SCYL2_S677 →	+0.637	+0.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904751 vs TUBG1 — OV

Explore this scatter interactively →