Positive regulation of protein localization to nucleolus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to nucleolus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMA16, KMT5C, and GLMN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMA16 grouped by Positive regulation of protein localization to nucleolus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMA16 →	+0.738	+0.464	<.001	.008	3	4
BLOOD_Myeloma	KMT5C →	+1.734	+0.463	.001	.005	2	4
LUNG_SCLC	GLMN →	+0.757	+0.416	.008	.004	3	3
LARGE_INTESTINE	PLAA →	+0.757	+0.560	<.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	RRP36 →	+1.017	+0.356	<.001	<.001	3	3
BLOOD_Leukemia	ST7L →	+0.866	+0.663	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMA16 by Positive regulation of protein localization to nucleolus activity — OVARY

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