Regulation of protein localization to nucleolus

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to nucleolus pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PA2G4, PINX1, and NOP58, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleolus activity versus PA2G4 in DLBC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	PA2G4 →	+0.730	+0.067	<.001	<.001	3	29
SKCM	PINX1 →	+0.833	+0.058	<.001	<.001	3	29
UVM	NOP58 →	+1.639	+0.061	<.001	<.001	3	29
KICH	CCT3 →	+0.753	+0.049	<.001	<.001	3	27
ACC	UTP14A →	+0.795	+0.038	<.001	.003	2	27
ACC	NOP56 →	+0.805	+0.034	.005	.006	1	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904749 vs PA2G4 — DLBC

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