Regulation of protein localization to nucleolus

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to nucleolus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, WDR43, and MSH2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleolus activity versus XPO5 in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	XPO5 →	+0.550	+0.121	<.001	<.001	3	8
LUAD	WDR43 →	+0.330	+0.094	<.001	<.001	3	7
HNSC	MSH2 →	+0.356	+0.072	<.001	<.001	3	7
HNSC	MSH6 →	+0.478	+0.127	<.001	<.001	3	7
LUAD	DDX52 →	+0.369	+0.104	<.001	<.001	3	6
UCEC	RSRC1 →	+0.274	+0.079	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904749 vs XPO5 — HNSC

Explore this scatter interactively →