Regulation of protein localization to nucleolus

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to nucleolus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACADM, RBBP8, and CRACD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleolus activity versus ACADM in BREAST (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACADM →	-0.937	-0.115	<.001	.001	3	5
LARGE_INTESTINE	RBBP8 →	-0.937	-0.095	<.001	.009	3	5
OVARY	CRACD →	-0.918	-0.074	.006	.005	3	5
LARGE_INTESTINE	TNFAIP3 →	+1.682	+0.124	.001	<.001	3	5
LARGE_INTESTINE	PSIP1 →	-0.859	-0.121	.003	.002	3	5
LIVER	GSDMB →	-1.267	-0.085	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904749 vs ACADM — BREAST

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