Regulation of apoptotic process involved in development

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA18, CYB561D1, and CA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic process involved in development activity versus SPATA18 in CCRCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPATA18 →	+0.549	+0.224	.002	.004	3	4
UCEC	CYB561D1 →	+0.342	+0.407	.003	.001	3	4
CCRCC	CA2 →	+0.499	+0.258	.006	<.001	3	3
OV	HMGXB4 →	-0.422	-0.359	<.001	.004	3	3
OV	PCARE →	+0.153	+0.426	<.001	.001	3	3
OV	LINC01093 →	+0.165	+0.447	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904748 vs SPATA18 — CCRCC

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