Regulation of apoptotic process involved in development

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic process involved in development pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are L3MBTL4, PPP2R2D, and CACNA1G, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, L3MBTL4 grouped by Regulation of apoptotic process involved in development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	L3MBTL4 →	+0.198	+0.201	.004	<.001	3	1
URINARY_TRACT	PPP2R2D →	-0.256	-1.718	.001	.001	2	2
LUNG_NSCLC_LUAD	CACNA1G →	-0.093	-1.338	.006	<.001	2	1
CNS	DUS4L →	+0.357	+0.180	.006	.003	2	1
CNS	SLC10A2 →	-0.196	-0.176	.005	.002	2	1
CNS	MPPE1 →	-0.355	-0.166	.005	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

L3MBTL4 by Regulation of apoptotic process involved in development activity — CNS

Explore this box plot interactively →