Positive regulation of apoptotic process involved in development

Across TCGA patient cohorts, RNA activity of the Positive regulation of apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF1B, CSF2RB, and IL2RB, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic process involved in development activity versus TNFRSF1B in LAML (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TNFRSF1B →	+1.910	+0.079	<.001	<.001	3	32
SCLC	CSF2RB →	+1.714	+0.195	<.001	<.001	3	30
SCLC	IL2RB →	+2.123	+0.213	<.001	<.001	3	30
SCLC	MYO1F →	+1.790	+0.206	<.001	<.001	3	30
KICH	GIMAP8 →	+1.347	+0.083	<.001	<.001	3	30
SCLC	SPI1 →	+1.469	+0.180	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904747 vs TNFRSF1B — LAML

Explore this scatter interactively →