Positive regulation of apoptotic process involved in development

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADCY1, MFSD10, and RPL26L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADCY1 grouped by Positive regulation of apoptotic process involved in development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ADCY1 →	+1.631	+1.220	.003	.006	3	3
URINARY_TRACT	MFSD10 →	+1.372	+1.713	.007	<.001	3	3
OESOPHAGUS	RPL26L1 →	-0.600	-0.566	<.001	.008	3	3
KIDNEY	ARMCX6 →	-0.827	-1.328	.001	.003	3	3
BLOOD_Leukemia	CAPNS2 →	-0.286	-1.358	.001	<.001	3	3
LARGE_INTESTINE	NT5E →	-1.974	-0.931	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADCY1 by Positive regulation of apoptotic process involved in development activity — URINARY_TRACT

Explore this box plot interactively →