Regulation of intestinal lipid absorption

Across TCGA patient cohorts, RNA activity of the Regulation of intestinal lipid absorption pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LPCAT3, PHB, and PHB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intestinal lipid absorption activity versus LPCAT3 in CCRCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LPCAT3 →	+0.809	+0.362	<.001	<.001	3	7
LUAD	PHB →	+0.274	+0.715	<.001	<.001	3	6
LUAD	PHB2 →	+0.366	+0.771	<.001	<.001	3	6
HNSC	YARS2 →	+0.368	+0.687	<.001	<.001	3	5
OV	FKBP4 →	+0.579	+0.146	.003	.002	3	5
CCRCC	MPRIP →	-0.285	-0.350	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904729 vs LPCAT3 — CCRCC

Explore this scatter interactively →