Regulation of intestinal lipid absorption

Across TCGA cell cohorts, RNA activity of the Regulation of intestinal lipid absorption pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC3, PCBP4, and MAPK6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5MC3 grouped by Regulation of intestinal lipid absorption-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATP5MC3 →	+0.733	+0.963	.002	.002	3	4
SOFT_TISSUE	PCBP4 →	-1.048	-1.448	.007	.001	3	4
PANCREAS	MAPK6 →	+0.762	+1.359	.005	<.001	3	4
LIVER	GPR180 →	-1.575	-1.464	<.001	.001	3	4
LUNG_SCLC	VKORC1L1 →	-0.722	-1.626	.004	<.001	3	4
LUNG_NSCLC_LUAD	UST →	+0.917	+0.863	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5MC3 by Regulation of intestinal lipid absorption activity — SKIN

Explore this box plot interactively →