Regulation of chaperone-mediated autophagy

Across TCGA patient cohorts, RNA activity of the Regulation of chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLK3, ATP13A2, and KLHL17, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chaperone-mediated autophagy activity versus PLK3 in CHOL (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	PLK3 →	+1.177	+0.071	<.001	<.001	3	25
MESO	ATP13A2 →	+0.892	+0.083	<.001	<.001	3	22
DLBC	KLHL17 →	+0.752	+0.082	.004	<.001	2	22
MESO	DVL1 →	+0.656	+0.071	.002	.001	1	22
PAAD	C1orf159 →	+0.487	+0.053	<.001	<.001	3	20
TGCT	ATAD3B →	+0.894	+0.079	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904714 vs PLK3 — CHOL

Explore this scatter interactively →