Regulation of chaperone-mediated autophagy

Across TCGA patient cohorts, RNA activity of the Regulation of chaperone-mediated autophagy pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, MAP7D1_S70, and LRRC25, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chaperone-mediated autophagy activity versus UTP25 in CCRCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	UTP25 →	-0.167	-0.052	.002	.003	3	6
HNSC	MAP7D1_S70 →	+0.757	+0.118	<.001	<.001	3	6
GBM	LRRC25 →	+0.575	+0.093	<.001	<.001	3	5
GBM	C5orf24 →	-0.330	-0.082	<.001	<.001	3	5
GBM	FKBP15_S1012 →	+0.371	+0.066	<.001	<.001	3	5
LSCC	LIG3 →	-0.449	-0.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904714 vs UTP25 — CCRCC

Explore this scatter interactively →