Regulation of chaperone-mediated autophagy

Across TCGA patient cohorts, RNA activity of the Regulation of chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS1, SH3GL1, and RAB8A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chaperone-mediated autophagy activity versus HMGCS1 in UCEC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGCS1 →	-0.614	-0.114	<.001	.002	3	4
GBM	SH3GL1 →	-0.311	-0.288	<.001	<.001	3	4
PDAC	RAB8A →	-0.179	-0.127	.008	.001	3	4
GBM	H2AX →	-0.621	-0.287	<.001	<.001	3	4
LSCC	CABP1 →	+0.237	+0.157	.001	<.001	3	4
LUAD	EEF1A2 →	+1.537	+0.166	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904714 vs HMGCS1 — UCEC

Explore this scatter interactively →