Regulation of chaperone-mediated autophagy

Across TCGA cell cohorts, RNA activity of the Regulation of chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INSYN1, GDPD5, and PTPN13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INSYN1 grouped by Regulation of chaperone-mediated autophagy-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INSYN1 →	-1.101	-0.259	.001	<.001	3	5
BLOOD_Leukemia	GDPD5 →	+1.369	+0.166	<.001	.003	3	4
SOFT_TISSUE	PTPN13 →	+1.601	+0.190	.004	.001	3	4
BREAST	TNNT1 →	-1.375	-0.148	.007	.006	3	4
BREAST	GPR68 →	-0.869	-0.160	<.001	.003	3	4
BREAST	SLC9A7 →	-1.172	-0.170	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INSYN1 by Regulation of chaperone-mediated autophagy activity — BONE

Explore this box plot interactively →