Regulation of chaperone-mediated autophagy

Across TCGA cell cohorts, RNA activity of the Regulation of chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK7, ENHO, and GFM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chaperone-mediated autophagy activity versus DOCK7 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DOCK7 →	+1.047	+0.205	<.001	<.001	3	5
BREAST	ENHO →	+1.179	+0.183	.003	.004	3	5
PANCREAS	GFM2 →	-0.560	-0.153	<.001	<.001	3	5
BREAST	BIK →	-1.354	-0.145	.005	.009	2	5
BREAST	NR4A3 →	+0.314	+0.124	.001	.007	3	4
BREAST	RHOQ →	+0.939	+0.159	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904714 vs DOCK7 — BREAST

Explore this scatter interactively →