Positive regulation of vascular associated smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AREL1, SERINC5, and NFYA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AREL1 grouped by Positive regulation of vascular associated smooth muscle cell proliferation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AREL1 →	+1.244	+0.428	.004	.007	3	4
LUNG_SCLC	SERINC5 →	-1.494	-0.292	.002	<.001	3	3
LUNG_NSCLC_LUAD	NFYA →	+0.619	+0.437	<.001	.006	3	3
LUNG_NSCLC_LUAD	RBP7 →	-1.374	-0.370	.001	.001	3	3
LUNG_NSCLC_LUAD	CHMP6 →	+0.600	+0.385	<.001	<.001	3	3
SKIN	MORN1 →	-1.094	-0.615	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AREL1 by Positive regulation of vascular associated smooth muscle cell proliferation activity — BLOOD_Myeloma

Explore this box plot interactively →