Positive regulation of vascular associated smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKACA, NOSTRIN, and TM2D3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular associated smooth muscle cell proliferation activity versus PRKACA in LUNG_SCLC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRKACA →	+0.497	+0.924	.007	.004	3	4
LUNG_NSCLC_LUAD	NOSTRIN →	-1.204	-1.044	.006	.002	3	4
LUNG_NSCLC_LUAD	TM2D3 →	-0.575	-0.983	.001	.001	3	4
SOFT_TISSUE	SAMD13 →	-1.494	-1.272	<.001	.003	3	3
LUNG_SCLC	SNX15 →	+0.833	+0.882	<.001	.002	3	3
BLOOD_Leukemia	LRP5 →	-0.897	-0.267	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904707 vs PRKACA — LUNG_SCLC

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