Negative regulation of vascular associated smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYBRD1, ATP8B2, and PDE5A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell proliferation activity versus CYBRD1 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYBRD1 →	+0.889	+0.217	.001	<.001	3	7
PDAC	ATP8B2 →	+0.384	+0.185	.006	.006	3	6
CCRCC	PDE5A →	+0.445	+0.132	<.001	.002	3	5
CCRCC	CASQ2 →	+1.059	+0.120	<.001	<.001	3	5
HNSC	CALCOCO1 →	+0.296	+0.137	<.001	.001	3	5
HNSC	LINC01359 →	+0.433	+0.137	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904706 vs CYBRD1 — UCEC

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