Negative regulation of vascular associated smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN1, NANOS1, and SNRNP27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SESN1 grouped by Negative regulation of vascular associated smooth muscle cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SESN1 →	-0.964	-1.185	.001	<.001	3	5
LARGE_INTESTINE	NANOS1 →	+1.234	+0.816	.009	.006	3	5
PANCREAS	SNRNP27 →	+0.513	+1.009	.002	.006	3	5
SOFT_TISSUE	MID1 →	+2.698	+1.294	<.001	.001	2	5
SOFT_TISSUE	DDB2 →	-1.220	-1.225	.006	.001	3	4
SOFT_TISSUE	LMO7 →	+3.486	+1.462	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SESN1 by Negative regulation of vascular associated smooth muscle cell proliferation activity — SKIN

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