Negative regulation of vascular associated smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of vascular associated smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD2, TRIM16, and IFT57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vascular associated smooth muscle cell proliferation activity versus SOD2 in CNS (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SOD2 →	+0.939	+0.169	.005	<.001	3	5
OVARY	TRIM16 →	+1.001	+0.271	.005	<.001	3	5
SKIN	IFT57 →	+0.703	+0.276	.004	<.001	3	5
URINARY_TRACT	AKR1C1 →	+2.826	+0.473	.002	<.001	3	5
OVARY	CASK →	+0.790	+0.216	.004	.006	3	5
BLOOD_Myeloma	STK24 →	+1.089	+0.524	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904706 vs SOD2 — CNS

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