Positive regulation of cytoplasmic translational initiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCK1, CLIC2, and NECAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translational initiation activity versus NCK1 in UCEC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCK1 →	+0.318	+0.079	<.001	<.001	3	6
BRCA	CLIC2 →	+0.554	+0.043	<.001	<.001	3	6
BRCA	NECAP2 →	+0.276	+0.044	<.001	<.001	3	6
CCRCC	COG4 →	-0.232	-0.059	<.001	<.001	3	6
UCEC	GIMAP1 →	+0.384	+0.064	<.001	<.001	3	5
UCEC	IL16 →	+0.575	+0.072	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904690 vs NCK1 — UCEC

Explore this scatter interactively →