Positive regulation of cytoplasmic translational initiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are METTL3_S50, GYG1_S337, and ZNF219_T257, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translational initiation activity versus METTL3_S50 in HNSC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	METTL3_S50 →	+0.767	+0.850	<.001	<.001	2	6
CCRCC	GYG1_S337 →	+0.582	+0.961	<.001	<.001	3	4
OV	ZNF219_T257 →	+2.408	+0.253	<.001	<.001	3	3
OV	NOS3 →	-1.018	-0.157	<.001	<.001	3	3
GBM	SRRM2_S2018 →	-0.615	-1.073	<.001	<.001	3	3
OV	XIRP1_S205 →	-1.281	-0.167	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904690 vs METTL3_S50 — HNSC

Explore this scatter interactively →