Positive regulation of cytoplasmic translational initiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoplasmic translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9B2, FAM114A1, and LIPG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translational initiation activity versus SLC9B2 in OVARY (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC9B2 →	+1.164	+0.851	.004	.004	3	5
OVARY	FAM114A1 →	+1.463	+0.786	.001	.005	3	5
OVARY	LIPG →	-2.857	-0.976	.001	.004	3	4
BONE	NUPR1 →	-4.481	-1.730	.006	.008	3	4
OVARY	F2R →	+2.030	+0.828	.003	.003	2	5
OVARY	LIX1L →	+1.759	+0.970	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904690 vs SLC9B2 — OVARY

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