Regulation of cytoplasmic translational initiation

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRF1, ZMYND8, and DUSP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRF1 grouped by Regulation of cytoplasmic translational initiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NRF1 →	-0.608	-0.257	<.001	.002	3	4
CNS	ZMYND8 →	-0.897	-0.289	<.001	<.001	3	3
CNS	DUSP6 →	-1.767	-0.274	.004	<.001	3	3
SKIN	CDKN1A →	-2.658	-0.563	<.001	.001	3	3
SKIN	PCDH7 →	-1.916	-0.653	.002	.008	2	4
SKIN	SESN1 →	-1.182	-0.362	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRF1 by Regulation of cytoplasmic translational initiation activity — PANCREAS

Explore this box plot interactively →