Regulation of cytoplasmic translational initiation

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQLE, CLDND2, and ANTXR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytoplasmic translational initiation activity versus SQLE in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SQLE →	+2.644	+0.102	.002	.008	3	4
BLOOD_Lymphoma	CLDND2 →	-1.029	-0.124	.008	.005	3	4
BLOOD_Lymphoma	ANTXR2 →	-2.993	-0.121	<.001	.003	3	4
STOMACH	GMPR →	-2.158	-0.186	.007	<.001	3	4
LARGE_INTESTINE	CHD7 →	+0.768	+0.143	.008	<.001	3	4
LUNG_SCLC	EPX →	-0.127	-0.125	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904688 vs SQLE — BLOOD_Lymphoma

Explore this scatter interactively →