Regulation of somatic stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of somatic stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG20, STX18, and ARHGAP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of somatic stem cell population maintenance activity versus ISG20 in HNSC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ISG20 →	-0.712	-0.084	<.001	.001	3	6
BRCA	STX18 →	-0.367	-0.043	<.001	<.001	3	6
HNSC	ARHGAP4 →	-0.369	-0.088	<.001	.001	3	6
COAD	DMXL1 →	-0.229	-0.034	.001	<.001	3	6
HNSC	CRLF3 →	-0.265	-0.094	.004	.001	3	6
LSCC	ENPP4 →	-0.364	-0.088	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904672 vs ISG20 — HNSC

Explore this scatter interactively →