Regulation of somatic stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of somatic stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP126, DSE, and ZNF384, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP126 grouped by Regulation of somatic stem cell population maintenance-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CEP126 →	-0.762	-0.732	.004	.008	3	4
OESOPHAGUS	DSE →	-1.919	-0.264	<.001	.001	3	4
LARGE_INTESTINE	ZNF384 →	-0.712	-0.187	.009	.003	2	4
PANCREAS	ATP5MPL →	+0.808	+0.229	.003	.001	3	3
KIDNEY	SGK3 →	+0.702	+1.240	.006	.003	3	3
LUNG_NSCLC_LUSC	KIF21A →	-1.095	-0.242	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP126 by Regulation of somatic stem cell population maintenance activity — CNS

Explore this box plot interactively →