Negative regulation of ubiquitin protein ligase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG2, RPL24, and COMMD2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin protein ligase activity activity versus BAG2 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BAG2 →	+0.612	+0.137	<.001	<.001	3	10
COAD	RPL24 →	+0.330	+0.082	<.001	<.001	3	3
GBM	COMMD2 →	+0.238	+0.084	.004	.005	3	3
GBM	RPS8 →	+0.238	+0.115	.001	.001	3	3
GBM	RPL32 →	+0.284	+0.114	<.001	.002	3	3
GBM	TRAJ6 →	-0.871	-0.106	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904667 vs BAG2 — BRCA

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