Negative regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN8, EPC1, and ZNF800, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBXN8 grouped by Negative regulation of ubiquitin protein ligase activity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	UBXN8 →	-1.104	-0.241	<.001	<.001	3	4
BLOOD_Myeloma	EPC1 →	-1.133	-0.244	<.001	<.001	3	4
BLOOD_Myeloma	ZNF800 →	-0.835	-0.203	.002	.005	3	4
CNS	SMAD5 →	-0.530	-0.130	.004	.003	3	4
LARGE_INTESTINE	GGA1 →	-0.845	-0.109	.001	<.001	3	4
LARGE_INTESTINE	CHMP7 →	-0.832	-0.129	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBXN8 by Negative regulation of ubiquitin protein ligase activity activity — BLOOD_Myeloma

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