Negative regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin protein ligase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA1, AKT2, and STK11IP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA1 grouped by Negative regulation of ubiquitin protein ligase activity-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ITGA1 →	+0.438	+0.176	.001	.001	3	5
OVARY	AKT2 →	-0.209	-0.135	.004	.005	3	4
STOMACH	STK11IP →	+0.182	+0.157	.005	.003	3	4
LUNG_NSCLC_LUSC	HP →	-0.238	-0.157	.003	.002	3	4
PANCREAS	MYLK4 →	-0.276	-0.219	.001	<.001	2	5
BREAST	FOXJ1 →	-0.189	-0.153	.005	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA1 by Negative regulation of ubiquitin protein ligase activity activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →