Negative regulation of ubiquitin protein ligase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH3B, ULBP1, and ABHD14B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin protein ligase activity activity versus IDH3B in LUNG_SCLC (Pearson r = -0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IDH3B →	-0.839	-1.900	.005	<.001	3	1
LUNG_SCLC	ULBP1 →	+2.710	+1.923	<.001	<.001	3	1
LUNG_SCLC	ABHD14B →	-1.930	-1.875	.008	<.001	3	1
LUNG_SCLC	CD274 →	+1.133	+1.940	.004	<.001	3	1
LUNG_SCLC	SMUG1 →	-0.853	-1.875	.006	<.001	3	1
LUNG_SCLC	ULBP2 →	+3.053	+1.923	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904667 vs IDH3B — LUNG_SCLC

Explore this scatter interactively →