Cellular response to amyloid-beta

Across TCGA patient cohorts, RNA activity of the Cellular response to amyloid-beta pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CH25H, KIF15, and REXO5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to amyloid-beta activity versus CH25H in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CH25H →	+1.046	+0.456	<.001	.004	3	5
GBM	KIF15 →	-1.024	-0.320	<.001	<.001	3	5
LSCC	REXO5 →	-0.571	-0.231	.006	<.001	3	5
GBM	CCNF →	-0.443	-0.296	<.001	<.001	3	5
LSCC	KIF22 →	-0.719	-0.317	.001	<.001	3	5
OV	TWIST2 →	+0.833	+0.210	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904646 vs CH25H — UCEC

Explore this scatter interactively →