Cellular response to amyloid-beta

Across TCGA cell cohorts, RNA activity of the Cellular response to amyloid-beta pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC22A, AKAP1, and NOLC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to amyloid-beta activity versus SEC22A in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SEC22A →	+0.665	+0.597	.001	.009	3	4
LARGE_INTESTINE	AKAP1 →	-0.771	-0.743	.009	.004	3	4
SKIN	NOLC1 →	-0.778	-0.251	<.001	.004	3	4
STOMACH	TLCD1 →	-0.951	-0.839	<.001	.004	3	4
LARGE_INTESTINE	ENGASE →	-1.611	-0.777	<.001	.004	3	4
SOFT_TISSUE	TBL3 →	-0.455	-0.200	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904646 vs SEC22A — LUNG_NSCLC_LUAD

Explore this scatter interactively →