Response to phorbol 13-acetate 12-myristate

Across TCGA patient cohorts, RNA activity of the Response to phorbol 13-acetate 12-myristate pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBP1, ZC3H12D, and BATF, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to phorbol 13-acetate 12-myristate activity versus FBP1 in CHOL (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	FBP1 →	+1.769	+0.094	<.001	<.001	2	29
ESCA	ZC3H12D →	+0.766	+0.063	<.001	<.001	3	23
CHOL	BATF →	+1.915	+0.082	<.001	<.001	3	22
SCLC	DPEP2 →	+1.020	+0.139	<.001	<.001	3	22
SCLC	ABI3 →	+1.557	+0.151	.003	<.001	3	21
SCLC	ARHGAP45 →	+1.488	+0.145	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904627 vs FBP1 — CHOL

Explore this scatter interactively →